Ca2+-activated Cl- channels in corpus cavernosum smooth muscle: a novel mechanism for control of penile erection.

@article{Karkanis2003Ca2activatedCC,
  title={Ca2+-activated Cl- channels in corpus cavernosum smooth muscle: a novel mechanism for control of penile erection.},
  author={Tom Karkanis and Ling DeYoung and Gerald B. Brock and Stephen Michael Sims},
  journal={Journal of applied physiology},
  year={2003},
  volume={94 1},
  pages={301-13}
}
Little is known of the excitatory mechanisms that contribute to the tonic contraction of the corpus cavernosum smooth muscle in the flaccid state. We used patch-clamp electrophysiology to investigate a previously unidentified inward current in freshly isolated rat and human corporal myocytes. Phenylephrine (PE) contracted cells and activated whole cell currents. Outward current was identified as large-conductance Ca(2+)-activated K(+) current. The inward current elicited by PE was dependent on… CONTINUE READING

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