Ca2+-activated Cl– channels in Ehrlich ascites tumor cells are distinct from mCLCA1, 2 and3

@article{Papassotiriou2001Ca2activatedCC,
  title={Ca2+-activated Cl– channels in Ehrlich ascites tumor cells are distinct from mCLCA1, 2 and3},
  author={Jana Papassotiriou and Jan Eggermont and Guy Droogmans and Bernd Nilius},
  journal={Pfl{\"u}gers Archiv},
  year={2001},
  volume={442},
  pages={273-279}
}
Using the whole-cell patch-clamp technique, we have studied the electrophysiological and pharmacological properties of the Ca2+-activated Cl– current present in Ehrlich cells. The currents activated slowly upon depolarization, deactivated upon hyperpolarization, and showed strong outward rectification. An increase in [Ca2+]i activated the current with an EC50 of 165.2 nM. Extracellular application of niflumic acid (100 µM) rapidly blocked the current in a voltage-dependent manner whereas… CONTINUE READING

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