Ca2+ Regulation of Cav3.3 T-type Ca2+ Channel Is Mediated by Calmodulin.

  title={Ca2+ Regulation of Cav3.3 T-type Ca2+ Channel Is Mediated by Calmodulin.},
  author={N J Lee and Sua Jeong and Kang-Chang Kim and Jin-ah Kim and Jin-Yong Park and Ho-Won Kang and Edward Perez-Reyes and Jung-ha Lee},
  journal={Molecular pharmacology},
  volume={92 3},
Calcium-dependent inactivation of high voltage-activated Ca2+ channels plays a crucial role in limiting rises in intracellular calcium (Ca2+i). A key mediator of these effects is calmodulin, which has been found to bind the C-terminus of the pore-forming α subunit. In contrast, little is known about how Ca2+i can regulate low voltage-activated T-type Ca2+ channels. Using whole cell patch clamp, we examined the biophysical properties of Ca2+ current through the three T-type Ca2+ channel isoforms… CONTINUE READING
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