Ca2+ Pulses Control Local Cycles of Lamellipodia Retraction and Adhesion along the Front of Migrating Cells

@article{Tsai2012Ca2PC,
  title={Ca2+ Pulses Control Local Cycles of Lamellipodia Retraction and Adhesion along the Front of Migrating Cells},
  author={Feng-Chiao Tsai and Tobias Meyer},
  journal={Current Biology},
  year={2012},
  volume={22},
  pages={837-842}
}
Ca(2+) signals regulate polarization, speed, and turning of migrating cells. However, the molecular mechanism by which Ca(2+) acts on moving cells is not understood. Here we show that local Ca(2+) pulses along the front of migrating human endothelial cells trigger cycles of retraction of local lamellipodia and, concomitantly, strengthen local adhesion to the extracellular matrix. These Ca(2+) release pulses had small amplitudes and diameters and were triggered repetitively near the leading… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 2 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 38 extracted citations

New insights into the role of mitochondrial calcium homeostasis in cell migration

Biochemical and biophysical research communications • 2018
View 4 Excerpts
Highly Influenced

The function of TRP channels in neutrophil granulocytes

Pflügers Archiv - European Journal of Physiology • 2018

References

Publications referenced by this paper.
Showing 1-10 of 24 references

Signaling pathways that control cell migration: models and analysis.

Wiley interdisciplinary reviews. Systems biology and medicine • 2011
View 1 Excerpt

Navigating through models of chemotaxis.

Current opinion in cell biology • 2008
View 2 Excerpts

Similar Papers

Loading similar papers…