Ca2+ Ions Regulate Activity of Na+,Cl–(HCO 3 − )-ATPase in the Mucosa of Rabbit Small Intestine


We studied the effects of bivalent metal ions on activity of Na+,Cl–(HCO3 –)-ATPase was studied. In contrast to Ba2+, Co2+, Zn2+, and Mn2+ ions, Ca2+ and Mg2+ ions in a concentration of 0.25 mM completely inhibited this enzyme. Histamine in vivo significantly decreased the inhibiting effect of Ca2+ on Na+,Cl–(HCO3 –)-ATPase. A possible mechanism of… (More)
DOI: 10.1007/s10517-015-2753-8

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