Ca2+ Induces a Cyclosporin A-Insensitive Permeability Transition Pore in Isolated Potato Tuber Mitochondria Mediated by Reactive Oxygen Species

@article{Fortes2001Ca2IA,
  title={Ca2+ Induces a Cyclosporin A-Insensitive Permeability Transition Pore in Isolated Potato Tuber Mitochondria Mediated by Reactive Oxygen Species},
  author={F Fortes and Roger F Castilho and Rosana Catisti and Eva Gunilla Skare Carnieri and Anibal E Vercesi},
  journal={Journal of Bioenergetics and Biomembranes},
  year={2001},
  volume={33},
  pages={43-51}
}
Oxidative damage of mammalian mitochondria induced by Ca2+ and prooxidants is mediated by the attack of mitochondria-generated reactive oxygen species on membrane protein thiols promoting oxidation and cross-linkage that leads to the opening of the mitochondrial permeability transition pore (Castilho et al., 1995). In this study, we present evidence that deenergized potato tuber (Solanum tuberosum) mitochondria, which do not possess a Ca2+ uniport, undergo inner membrane permeabilization when… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 28 CITATIONS

The mitochondrial permeability transition pore (PTP) - an example of multiple molecular exaptation?

  • Biochimica et biophysica acta
  • 2012
VIEW 18 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

The Permeability Transition in Plant Mitochondria: The Missing Link

  • Front. Plant Sci.
  • 2015
VIEW 2 EXCERPTS
CITES RESULTS & BACKGROUND