Ca2+ Extrusion by NCX Is Compromised in Olfactory Sensory Neurons of OMP−/− Mice

@article{Kwon2009Ca2EB,
  title={Ca2+ Extrusion by NCX Is Compromised in Olfactory Sensory Neurons of OMP−/− Mice},
  author={Hyun Jin Kwon and Jae Hyung Koo and Frank Zufall and Trese Leinders-Zufall and Frank L. Margolis},
  journal={PLoS ONE},
  year={2009},
  volume={4},
  pages={452 - 462}
}
BACKGROUND The role of olfactory marker protein (OMP), a hallmark of mature olfactory sensory neurons (OSNs), has been poorly understood since its discovery. The electrophysiological and behavioral phenotypes of OMP knockout mice indicated that OMP influences olfactory signal transduction. However, the mechanism by which this occurs remained unknown. PRINCIPAL FINDINGS We used intact olfactory epithelium obtained from WT and OMP(-/-) mice to monitor the Ca(2+) dynamics induced by the… CONTINUE READING
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