Ca2+-Dependent Synaptotagmin Binding to SNAP-25 Is Essential for Ca2+-Triggered Exocytosis

@article{Zhang2002Ca2DependentSB,
  title={Ca2+-Dependent Synaptotagmin Binding to SNAP-25 Is Essential for Ca2+-Triggered Exocytosis},
  author={Xiaodong Zhang and Mindy J. Kim-Miller and Mitsunori Fukuda and Judith A. Kowalchyk and Thomas F J Martin},
  journal={Neuron},
  year={2002},
  volume={34},
  pages={599-611}
}
Synaptotagmin is a proposed Ca2+ sensor on the vesicle for regulated exocytosis and exhibits Ca2+-dependent binding to phospholipids, syntaxin, and SNAP-25 in vitro, but the mechanism by which Ca2+ triggers membrane fusion is uncertain. Previous studies suggested that SNAP-25 plays a role in the Ca2+ regulation of secretion. We found that synaptotagmins I and IX associate with SNAP-25 during Ca2+-dependent exocytosis in PC12 cells, and we identified C-terminal amino acids in SNAP-25 (Asp179… CONTINUE READING
91 Citations
57 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 91 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 57 references

Synaptotagmin IV is present at the Golgi and distal parts Shoji-Kasai

  • 2000
Highly Influential
4 Excerpts

substrate complexes and cleavage

  • J. T. Littleton, J. Bai, +11 authors E. R. Chapman
  • J. Neurochem
  • 2001
Highly Influential
7 Excerpts

Multiple kinetic Martin, T.F.J., and Kowalchyk, J.A

  • T. Xu, T. Binz, H. Niemann, E. Neher
  • J. Biol. Nat. Neurosci
  • 1998
Highly Influential
5 Excerpts

Synaptotagmin VII as a plasma mem - 150 , 719 – 730 . brane Ca 2  sensor in exocytosis

  • S. Sugita, W. Han, S. Butz, X. Liu, R. Fernandez-Chacon, T. C. Sudhof
  • Neuron
  • 2001
1 Excerpt

Synaptotagmins Jahn, R

  • T. Xu, B. Rammner, +5 authors M. Seagar
  • Cell 99,
  • 2000

Similar Papers

Loading similar papers…