Ca2+ Binding Protein Frequenin Mediates GDNF-Induced Potentiation of Ca2+ Channels and Transmitter Release

@article{Wang2001Ca2BP,
  title={Ca2+ Binding Protein Frequenin Mediates GDNF-Induced Potentiation of Ca2+ Channels and Transmitter Release},
  author={Chang-Yu Wang and Feng Yang and Xiangping He and Ana R Chow and Jing Du and James T. Russell and Bai Lu},
  journal={Neuron},
  year={2001},
  volume={32},
  pages={99-112}
}
Molecular mechanisms underlying long-term neurotrophic regulation of synaptic transmission and plasticity are unknown. We report here that long-term treatment of neuromuscular synapses with glial cell line-derived neurotrophic factor (GDNF) potentiates spontaneous and evoked transmitter release, in ways very similar to presynaptic expression of the Ca(2+) binding protein frequenin. GDNF enhances the expression of frequenin in motoneurons, and inhibition of frequenin expression or activity… CONTINUE READING