Ca2+–calmodulin signalling pathway up-regulates GABA synaptic transmission through cytoskeleton-mediated mechanisms

@article{Wei2004Ca2calmodulinSP,
  title={Ca2+–calmodulin signalling pathway up-regulates GABA synaptic transmission through cytoskeleton-mediated mechanisms},
  author={Jizhen Wei and Michael Oglesbee Zhang and Yuanqiang Zhu and Jia-Huai Wang},
  journal={Neuroscience},
  year={2004},
  volume={127},
  pages={637-647}
}
We investigated the role of calcium (Ca(2+))/calmodulin (CaM) signaling pathways in modulating GABA synaptic transmission at CA1 pyramidal neurons in hippocampal slices. Whole-cell pipettes were used to record type A GABA receptor (GABA(A)R)-gated inhibitory postsynaptic currents (IPSCs) and to perfuse intracellularly modulators in the presence of glutamate receptor antagonists. GABA(A)R-gated IPSCs were enhanced by the postsynaptic infusions of adenophostin (1 microM), a potent agonist of… CONTINUE READING
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