Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.

@article{Woods2005Ca2calmodulindependentPK,
  title={Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.},
  author={Angela Woods and Kristina Dickerson and Richard Heath and S. Hong and Milica Momcilovic and Stephen R. Johnstone and M. Carlson and David Carling},
  journal={Cell metabolism},
  year={2005},
  volume={2 1},
  pages={21-33}
}
AMP-activated protein kinase (AMPK) is the downstream component of a kinase cascade that plays a pivotal role in energy homeostasis. Activation of AMPK requires phosphorylation of threonine 172 (T172) within the T loop region of the catalytic alpha subunit. Recently, LKB1 was shown to activate AMPK. Here we show that AMPK is also activated by Ca(2+)/calmodulin-dependent protein kinase kinase (CaMKK). Overexpression of CaMKKbeta in mammalian cells increases AMPK activity, whereas pharmacological… CONTINUE READING
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