Ca2+/calmodulin-dependent protein kinase IV-mediated LIM kinase activation is critical for calcium signal-induced neurite outgrowth.

@article{Takemura2009Ca2calmodulindependentPK,
  title={Ca2+/calmodulin-dependent protein kinase IV-mediated LIM kinase activation is critical for calcium signal-induced neurite outgrowth.},
  author={Miyohiko Takemura and Toshiaki Mishima and Yan Wang and Jiro Kasahara and Kohji Fukunaga and Kazumasa Ohashi and Kensaku Mizuno},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 42},
  pages={
          28554-62
        }
}
  • Miyohiko Takemura, Toshiaki Mishima, +4 authors Kensaku Mizuno
  • Published in
    The Journal of biological…
    2009
  • Biology, Medicine
  • Actin cytoskeletal remodeling is essential for neurite outgrowth. LIM kinase 1 (LIMK1) regulates actin cytoskeletal remodeling by phosphorylating and inactivating cofilin, an actin filament-disassembling factor. In this study, we investigated the role of LIMK1 in calcium signal-induced neurite outgrowth. The calcium ionophore ionomycin induced LIMK1 activation and cofilin phosphorylation in Neuro-2a neuroblastoma cells. Knockdown of LIMK1 or expression of a kinase-dead mutant of LIMK1… CONTINUE READING

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