Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-kappaB activation.

@article{Ishiguro2006Ca2calmodulindependentPK,
  title={Ca2+/calmodulin-dependent protein kinase II is a modulator of CARMA1-mediated NF-kappaB activation.},
  author={Kazuhiro Ishiguro and Todd J. Green and Joseph Rapley and Heather Wachtel and Cosmas Giallourakis and Aimee L Landry and Zhifang Cao and Naifang Lu and Ando Takafumi and Hidemi Goto and Mark J. Daly and Ramnik J. Xavier},
  journal={Molecular and cellular biology},
  year={2006},
  volume={26 14},
  pages={5497-508}
}
CARMA1 is a central regulator of NF-kappaB activation in lymphocytes. CARMA1 and Bcl10 functionally interact and control NF-kappaB signaling downstream of the T-cell receptor (TCR). Computational analysis of expression neighborhoods of CARMA1-Bcl10MALT 1 for enrichment in kinases identified calmodulin-dependent protein kinase II (CaMKII) as an important component of this pathway. Here we report that Ca(2+)/CaMKII is redistributed to the immune synapse following T-cell activation and that CaMKII… CONTINUE READING