Ca2+/calmodulin-dependent protein kinase II in the spinal cord contributes to neuropathic pain in a rat model of mononeuropathy.

@article{Dai2005Ca2calmodulindependentPK,
  title={Ca2+/calmodulin-dependent protein kinase II in the spinal cord contributes to neuropathic pain in a rat model of mononeuropathy.},
  author={Yi Dai and Hu Wang and Akiko Ogawa and Hiroki Yamanaka and Koichi Obata and Atsushi Tokunaga and Koichi Noguchi},
  journal={The European journal of neuroscience},
  year={2005},
  volume={21 9},
  pages={2467-74}
}
Ca2+/calmodulin-dependent protein kinase II (CaMKII) is known to subserve activity-dependent neuronal plasticity in the central nervous system. To examine in vivo the implication of spinal CaMKII activity in the generation and development of neuropathic pain after peripheral nerve injury, we used an animal model of mononeuropathy, the chronic constriction injury (CCI) model, in the rat. We found that, 3 days after CCI, the total CaMKII (tCaMKII) immunoreactivity increased in the superficial… CONTINUE READING
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