Ca2+/calmodulin-dependent protein kinase II in postsynaptic densities after reversible cerebral ischemia in rats.

@article{Aronowski1996Ca2calmodulindependentPK,
  title={Ca2+/calmodulin-dependent protein kinase II in postsynaptic densities after reversible cerebral ischemia in rats.},
  author={Jaroslaw Aronowski and James C. Grotta},
  journal={Brain research},
  year={1996},
  volume={709 1},
  pages={103-10}
}
Compartmentalization of protein kinases and association of the enzyme with strategic cellular substrates may be important for regulating signal transduction in neurons. Cerebral ischemia produced by transient 20 min occlusion of common carotid and vertebral arteries in rats caused a dramatic (3-fold) increase in Ca2+/Calmodulin-dependent protein kinase II (CaM-KII) in the fraction enriched in postsynaptic density (PSDf), the compartment of the neuron that is involved in signal transduction… CONTINUE READING