Ca2+/calmodulin-dependent protein kinase II delta2 regulates gene expression of insulin in INS-1 rat insulinoma cells.

@article{Osterhoff2003Ca2calmodulindependentPK,
  title={Ca2+/calmodulin-dependent protein kinase II delta2 regulates gene expression of insulin in INS-1 rat insulinoma cells.},
  author={M Osterhoff and Matthias M{\"o}hlig and Mathias Schwanstecher and Jochen Seufert and Jana Ortmann and Helmut Schatz and Andreas F. H. Pfeiffer},
  journal={Cell calcium},
  year={2003},
  volume={33 3},
  pages={175-84}
}
Ca(2+)/calmodulin-dependent protein kinase II is a member of a broad family of ubiquitously expressed Ca(2+) sensing serine/threonine-kinases. Ca(2+)/calmodulin-dependent protein kinase II is highly expressed in insulin secreting cells and is associated with insulin secretory granules and has been proposed to play an important role in exocytosis or in insulin granule transport to release sites. To elucidate its function the antisense sequence of the major beta-cell subtype, Ca(2+)/calmodulin… CONTINUE READING

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