Ca2+/calmodulin-dependent protein kinase II and protein kinase A differentially regulate sarcoplasmic reticulum Ca2+ leak in human cardiac pathology.

@article{Fischer2013Ca2calmodulindependentPK,
  title={Ca2+/calmodulin-dependent protein kinase II and protein kinase A differentially regulate sarcoplasmic reticulum Ca2+ leak in human cardiac pathology.},
  author={Thomas Fischer and Jonas Herting and Theodor Tirilomis and Andr{\'e} Renner and Stefan Neef and Karl Toischer and David Ellenberger and Anna F{\"o}rster and Jan Dieter Schmitto and Jan F. Gummert and Friedrich Albert Schoendube and Gerd Hasenfuss and Lars Siegfried Maier and Samuel T. Sossalla},
  journal={Circulation},
  year={2013},
  volume={128 9},
  pages={970-81}
}
BACKGROUND Sarcoplasmic reticulum (SR) Ca(2+) leak through ryanodine receptor type 2 (RyR2) dysfunction is of major pathophysiological relevance in human heart failure (HF); however, mechanisms underlying progressive RyR2 dysregulation from cardiac hypertrophy to HF are still controversial. METHODS AND RESULTS We investigated healthy control myocardium (n=5) and myocardium from patients with compensated hypertrophy (n=25) and HF (n=32). In hypertrophy, Ca(2+)/calmodulin-dependent protein… CONTINUE READING
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