Ca2+/Calmodulin-Dependent Protein Kinase II γ-Dependent Serine727 Phosphorylation Is Required for TMEM16A Ca2+-Activated Cl- Channel Regulation in Cerebrovascular Cells.

@article{Lin2018Ca2CalmodulinDependentPK,
  title={Ca2+/Calmodulin-Dependent Protein Kinase II γ-Dependent Serine727 Phosphorylation Is Required for TMEM16A Ca2+-Activated Cl- Channel Regulation in Cerebrovascular Cells.},
  author={Cai-Xia Lin and Xiaofei Lv and F. -M. Yuan and Xiang-Yu Li and Ming-Ming Ma and Can-Zhao Liu and Jia-guo Zhou and Guan-lei Wang and Yong-Yuan Guan},
  journal={Circulation journal : official journal of the Japanese Circulation Society},
  year={2018},
  volume={82 3},
  pages={903-913}
}
BACKGROUND TMEM16A is a critical component of Ca2+-activated chloride channels (CaCCs) and mediates basilar arterial smooth muscle cell (BASMC) proliferation in hypertensive cerebrovascular remodeling. CaMKII is a negative regulator of CaCC, and four CaMKII isoforms (α, β, γ and δ) are expressed in vasculature; however, it is unknown which and how CaMKII… CONTINUE READING