Ca-stimulated type 8 adenylyl cyclase is required for rapid acquisition of novel spatial information and for working/episodic-like memory.

@article{Zhang2008CastimulatedT8,
  title={Ca-stimulated type 8 adenylyl cyclase is required for rapid acquisition of novel spatial information and for working/episodic-like memory.},
  author={Ming Zhang and Changjong Moon and Guy C. K. Chan and Lan Yang and Fei Zheng and Alana C. Conti and Lisa M. Muglia and Louis J. Muglia and Daniel R Storm and Hongbing Wang},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2008},
  volume={28 18},
  pages={4736-44}
}
Ca-stimulated adenylyl cyclases (ACs) transduce neuronal stimulation-evoked increase in calcium to the production of cAMP, which impinges on the regulation of many aspects of neuronal function. Type 1 and type 8 AC (AC1 and AC8) are the only ACs that are directly stimulated by Ca. Although AC1 function was implicated in regulating reference spatial memory, the function of AC8 in memory formation is not known. Because of the different biochemical properties of AC1 and AC8, these two enzymes may… CONTINUE READING