Ca²+ spark-dependent and -independent sarcoplasmic reticulum Ca²+ leak in normal and failing rabbit ventricular myocytes.

Abstract

Sarcoplasmic reticulum (SR) Ca²(+) leak is an important component of cardiac Ca²(+) signalling. Together with the SR Ca²(+)-ATPase (SERCA)-mediated Ca²(+) uptake, diastolic Ca²(+) leak determines SR Ca²(+) load and, therefore, the amplitude of Ca²(+) transients that initiate contraction. Spontaneous Ca²(+) sparks are thought to play a major role in SR Ca… (More)
DOI: 10.1113/jphysiol.2010.197913

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Cite this paper

@article{Zima2010CaSA, title={Ca²+ spark-dependent and -independent sarcoplasmic reticulum Ca²+ leak in normal and failing rabbit ventricular myocytes.}, author={Aleksey V. Zima and Elisa Bovo and Donald M. Bers and Lothar A Blatter}, journal={The Journal of physiology}, year={2010}, volume={588 Pt 23}, pages={4743-57} }