Ca-Activated Na-Ca Exchange Activity in Canine Pacing-Induced Heart Failure

Abstract

Defective excitation-contraction coupling in heart failure is generally associated with both a reduction in sarcoplasmic reticulum (SR) Ca uptake and a greater dependence on transsarcolemmal Na-Ca exchange (NCX) for Ca removal. Although a relative increase in NCX is expected when SR function is impaired, few and contradictory studies have addressed whether… (More)

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