Ca(2+)-dependent inactivation of high-threshold Ca(2+) currents in hippocampal granule cells of patients with chronic temporal lobe epilepsy.

@article{Beck1999Ca2dependentIO,
  title={Ca(2+)-dependent inactivation of high-threshold Ca(2+) currents in hippocampal granule cells of patients with chronic temporal lobe epilepsy.},
  author={Heinz Beck and Reynaud Steffens and Uwe Heinemann and Christian Erich Elger},
  journal={Journal of neurophysiology},
  year={1999},
  volume={82 2},
  pages={946-54}
}
Intracellular Ca(2+) represents an important trigger for various second-messenger mediated effects. Therefore a stringent control of the intracellular Ca(2+) concentration is necessary to avoid excessive activation of Ca(2+)-dependent processes. Ca(2+)-dependent inactivation of voltage-dependent calcium currents (VCCs) represents an important negative feedback mechanism to limit the influx of Ca(2+) that has been shown to be altered in the kindling model of epilepsy. We therefore investigated… CONTINUE READING
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Properties of voltage-dependent sodium channels in isolated human hippocampal neurones

  • G. RECKZIEGEL, H. BECK, J. SCHRAMM, C. E. ELGER, B. W. URBAN
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