Ca(2+) channels and transmitter release at the active zone.

  title={Ca(2+) channels and transmitter release at the active zone.},
  author={Ralf Schneggenburger and Yunyun Han and Olexiy Kochubey},
  journal={Cell calcium},
  volume={52 3-4},
Ca(2+)-dependent transmitter release is the most important signaling mechanism for fast information transfer between neurons. Transmitter release takes places at highly specialized active zones with sub-micrometer dimension, which contain the molecular machinery for vesicle docking and -fusion, as well as a high density of voltage-gated Ca(2+) channels. In the absence of direct evidence for the ultrastructural localization of Ca(2+) channels at CNS synapses, important insights into Ca(2… CONTINUE READING