Ca²(+) transfer from the ER to mitochondria: channeling cell death by a tumor suppressor.


The mitochondrial gateway to cell death is a frequent target for tumor suppressors, which largely utilize Bcl-2-dependent apoptotic pathways. Reporting in Science, Giorgi et al. (2010) now show that PML exerts its tumor suppressor function via a distinct mechanism: Ca²(+) transfer from the endoplasmic reticulum to the mitochondria. 
DOI: 10.1016/j.devcel.2010.11.013


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