Ca(v)1.2 splice variant with exon 9* is critical for regulation of cerebral artery diameter.

@article{Nystoriak2009Cav12SV,
  title={Ca(v)1.2 splice variant with exon 9* is critical for regulation of cerebral artery diameter.},
  author={Matthew A Nystoriak and Kentaro Murakami and Paul L. Penar and George C. Wellman},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2009},
  volume={297 5},
  pages={H1820-8}
}
L-type voltage-dependent Ca(2+) channels (VDCCs) are essential for numerous processes in the cardiovascular and nervous systems. Alternative splicing modulates proteomic composition of Ca(v)1.2 to generate functional variation between channel isoforms. Here, we describe expression and function of Ca(v)1.2 channels containing alternatively spliced exon 9* in cerebral artery myocytes. RT-PCR showed expression of Ca(v)1.2 splice variants both containing (alpha(1)C(9/9*/10)) and lacking (alpha(1)C… CONTINUE READING