Ca(2+) sparks promote myogenic tone in retinal arterioles.

Abstract

BACKGROUND AND PURPOSE Ca(2+) imaging reveals subcellular Ca(2+) sparks and global Ca(2+) waves/oscillations in vascular smooth muscle. It is well established that Ca(2+) sparks can relax arteries, but we have previously reported that sparks can summate to generate Ca(2+) waves/oscillations in unpressurized retinal arterioles, leading to constriction. We… (More)
DOI: 10.1111/bph.12044

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