Ca(2+) spark sites in smooth muscle cells are numerous and differ in number of ryanodine receptors, large-conductance K(+) channels, and coupling ratio between them.

@article{Zhuge2004Ca2SS,
  title={Ca(2+) spark sites in smooth muscle cells are numerous and differ in number of ryanodine receptors, large-conductance K(+) channels, and coupling ratio between them.},
  author={Ronghua Zhuge and Kevin E. Fogarty and Stephen P. Baker and John G. McCarron and Richard A. Tuft and Lawrence M. Lifshitz and John V. Walsh},
  journal={American journal of physiology. Cell physiology},
  year={2004},
  volume={287 6},
  pages={C1577-88}
}
Ca(2+) sparks are highly localized Ca(2+) transients caused by Ca(2+) release from sarcoplasmic reticulum through ryanodine receptors (RyR). In smooth muscle, Ca(2+) sparks activate nearby large-conductance, Ca(2+)-sensitive K(+) (BK) channels to generate spontaneous transient outward currents (STOC). The properties of individual sites that give rise to Ca(2+) sparks have not been examined systematically. We have characterized individual sites in amphibian gastric smooth muscle cells with… CONTINUE READING

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