Ca(2+)-sensing receptor expression and PTHrP secretion in PC-3 human prostate cancer cells.

@article{Sanders2001Ca2sensingRE,
  title={Ca(2+)-sensing receptor expression and PTHrP secretion in PC-3 human prostate cancer cells.},
  author={J. L. Sanders and Naibedya Chattopadhyay and Olga Kifor and Takamasa Yamaguchi and Edward Meigs Brown},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2001},
  volume={281 6},
  pages={E1267-74}
}
Prostate cancer metastasizes frequently to bone. Elevated extracellular calcium concentrations ([Ca(2+)](o)) stimulate parathyroid hormone-related protein (PTHrP) secretion from normal and malignant cells, potentially acting via the [Ca(2+)](o)-sensing receptor (CaR). Because prostate cancers produce PTHrP, if high [Ca(2+)](o) stimulates PTHrP secretion via the CaR, this could initiate a mechanism whereby osteolysis caused by bony metastases of prostate cancer promotes further bone resorption… CONTINUE READING

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Thus , in PTHrP - secreting prostate cancers metastatic to bone , the CaR could initiate a vicious cycle , whereby PTHrP - induced bone resorption releases [ Ca(2+)](o ) and TGF - beta stored within bone , further increasing PTHrP release and osteolysis .
Because prostate cancers produce PTHrP , if high [ Ca(2+)](o ) stimulates PTHrP secretion via the CaR , this could initiate a mechanism whereby osteolysis caused by bony metastases of prostate cancer promotes further bone resorption .
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