Ca(2+) -related signaling events influence TLR9-induced IL-10 secretion in human B cells.

  title={Ca(2+) -related signaling events influence TLR9-induced IL-10 secretion in human B cells.},
  author={Saskia Ziegler and Katrin Gartner and Uwe Scheuermann and Tanja Zoeller and Julia Hantzschmann and Benjamin Over and Sandra Foermer and Klaus M Heeg and Isabelle Bekeredjian-Ding},
  journal={European journal of immunology},
  volume={44 5},
Suppressory B-cell function controls immune responses and is mainly dependent on IL-10 secretion. Pharmacological manipulation of B-cell-specific IL-10 synthesis could, thus, be therapeutically useful in B-cell chronic lymphocytic leukemia, transplantation, autoimmunity and sepsis. TLR are thought to play a protagonistic role in the formation of IL-10-secreting B cells. The aim of the study was to identify the molecular events selectively driving IL-10 production in TLR9-stimulated human B… CONTINUE READING


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