Ca(2+) mishandling and cardiac dysfunction in obesity and insulin resistance: role of oxidative stress.

Abstract

Obesity and insulin resistance (IR) are strongly connected to the development of subclinical cardiac dysfunction and eventually can lead to heart failure, which is the main cause of morbidity and death in patients having these metabolic diseases. It has been considered that excessive fat tissue may play a critical role in producing systemic IR and enhancing… (More)
DOI: 10.1016/j.ceca.2014.08.003

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