Ca(2+)-inositol phosphate chelation mediates the substrate specificity of beta-propeller phytase.

@article{Oh2006Ca2inositolPC,
  title={Ca(2+)-inositol phosphate chelation mediates the substrate specificity of beta-propeller phytase.},
  author={Byung-chul Oh and Myung Hee Kim and Bong-Sik Yun and Won-Chan Choi and S. Park and S C Bae and T I Oh},
  journal={Biochemistry},
  year={2006},
  volume={45 31},
  pages={9531-9}
}
Inositol phosphates are recognized as having diverse and critical roles in biological systems. In this report, kinetic studies and TLC analysis indicate that beta-propeller phytase is a special class of inositol phosphatase that preferentially recognizes a bidentate (P-Ca(2+)-P) formed between Ca(2+) and two adjacent phosphate groups of its natural substrate phytate (InsP(6)). The specific recognition of a bidentate chelation enables the enzyme to sequentially hydrolyze one of the phosphate… CONTINUE READING
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