Ca(2+)-independent release of glutamate during in vitro anoxia in isolated nerve terminals.

@article{Rubio1991Ca2independentRO,
  title={Ca(2+)-independent release of glutamate during in vitro anoxia in isolated nerve terminals.},
  author={Ivette Rubio and Manuel Torres and M Teresa Miras-Portugal and Jos{\'e} S{\'a}nchez-Prieto},
  journal={Journal of neurochemistry},
  year={1991},
  volume={57 4},
  pages={1159-64}
}
The effects of in vitro anoxia on the release of glutamate in isolated nerve terminals were studied. The extra-synaptosomal concentration of glutamate ([Glu]ext) under aerobic conditions was 2.3 microM and increased to 4.9 microM after 10 min of anoxia. However, when synaptosomes were incubated in the presence of lactate plus pyruvate instead of glucose, to prevent anaerobic glycolysis, anoxia induced an eightfold increase in the [Glu]ext. The accumulation of glutamate in the external medium… CONTINUE READING

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