Ca(2+)-independent but voltage-dependent secretion in mammalian dorsal root ganglion neurons.

@article{Zhang2002Ca2independentBV,
  title={Ca(2+)-independent but voltage-dependent secretion in mammalian dorsal root ganglion neurons.},
  author={C X Zhang and Zhuan Zhou},
  journal={Nature neuroscience},
  year={2002},
  volume={5 5},
  pages={425-30}
}
We have investigated the Ca(2+) dependence of vesicular secretion from the soma of dorsal root ganglion (DRG) neurons, which secrete neuropeptides by exocytosis of dense-core vesicles. In patch-clamped somata of rat DRG neurons, we found a depolarization-induced membrane capacitance increase (DeltaC(m)) in the absence of extracellular Ca(2+) and in the presence of a Ca(2+) chelator (BAPTA) in the intracellular solution. Depletion of internal Ca(2+) stores by thapsigargin in the Ca(2+)-free bath… CONTINUE READING

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