Ca(2+) homeostasis and structural and functional remodelling of airway smooth muscle in asthma.

@article{Mahn2010Ca2HA,
  title={Ca(2+) homeostasis and structural and functional remodelling of airway smooth muscle in asthma.},
  author={K. Mahn and Oluwaseun O. Ojo and Gianna Chadwick and Philip I Aaronson and Jeremy P T Ward and Tak Hong Lee},
  journal={Thorax},
  year={2010},
  volume={65 6},
  pages={547-52}
}
Asthma is characterised by airway hyper-responsiveness and remodelling, and there is mounting evidence that alterations in the phenotype of airway smooth muscle (ASM) play a central role in these processes. Although the concept that dysregulation of ASM Ca(2+) homeostasis may underlie at least part of these alterations has been around for many years, it is only relatively recently that the availability of ASM biopsies from subjects with mild and moderate asthma has allowed it to be properly… CONTINUE READING

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