Ca(2+)-force relationship of frog skeletal muscle: a dynamic model for parameter estimation.

@article{Shames1996Ca2forceRO,
  title={Ca(2+)-force relationship of frog skeletal muscle: a dynamic model for parameter estimation.},
  author={David M. Shames and Anthony J. Baker and Michael W Weiner and S. Albert Camacho},
  journal={The American journal of physiology},
  year={1996},
  volume={271 6 Pt 1},
  pages={C2062-71}
}
A simple mathematical model describing the dynamic connection between Ca2+ and force generation in intact skeletal muscle from the frog has been developed from isometric force responses to cytosolic Ca2+ concentration ([Ca2+]c) transients during tetanic and twitch contractions. The main element of the model is a two-state cross-bridge cycle characterized by the fractional rate of cross-bridge attachment (f(app)) and the fractional rate of cross-bridge detachment (g*). While g* is constant, f… CONTINUE READING