Ca(2+)-dependent regulation of TrkB expression in neurons.

@article{Kingsbury2003Ca2dependentRO,
  title={Ca(2+)-dependent regulation of TrkB expression in neurons.},
  author={Tami J Kingsbury and Peter D. Murray and Linda L. Bambrick and Bruce K. Krueger},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 42},
  pages={
          40744-8
        }
}
The neurotrophin brain-derived neurotrophic factor (BDNF), via activation of its receptor, tyrosine receptor kinase B (trkB), regulates a wide variety of cellular processes in the nervous system, including neuron survival and synaptic plasticity. Although the expression of BDNF is known to be Ca2+-dependent, the regulation of trkB expression has not been extensively studied. Here we report that depolarization of cultured mouse cortical neurons increased the expression of the full-length… CONTINUE READING

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