Ca(2+)-dependent interaction of triadin with histidine-rich Ca(2+)-binding protein carboxyl-terminal region.

@article{Sacchetto2001Ca2dependentIO,
  title={Ca(2+)-dependent interaction of triadin with histidine-rich Ca(2+)-binding protein carboxyl-terminal region.},
  author={Roberta Sacchetto and Ernesto Damiani and Federica Turcato and Alessandra Nori and Alfredo Margreth},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={289 5},
  pages={1125-34}
}
A direct binding of HRC (histidine-rich Ca(2+)-binding protein) to triadin, the main transmembrane protein of the junctional sarcoplasmic reticulum (SR) of skeletal muscle, seems well supported. Opinions are still divided, however, concerning the triadin domain involved, either the cytoplasmic or the lumenal domain, and the exact role played by Ca(2+), in the protein-to-protein interaction. Further support for colocalization of HRC with triadin cytoplasmic domain is provided here by experiments… CONTINUE READING