Ca(2+)-dependent binding of endonexin (annexin IV) to membranes: analysis of the effects of membrane lipid composition and development of a predictive model for the binding interaction.

@article{Junker1994Ca2dependentBO,
  title={Ca(2+)-dependent binding of endonexin (annexin IV) to membranes: analysis of the effects of membrane lipid composition and development of a predictive model for the binding interaction.},
  author={Matthew Junker and Carl E. Creutz},
  journal={Biochemistry},
  year={1994},
  volume={33 30},
  pages={8930-40}
}
Endonexin (annexin IV) is a member of the annexin family of homologous proteins that bind membranes and aggregate vesicles in a calcium-dependent fashion. This study examines the lipid modulation and mechanism of the binding of endonexin to membranes using a fluorescence energy transfer assay to measure bovine endonexin binding to well-defined large unilamellar vesicles. The calcium sensitivity for endonexin-membrane binding is observed to be highly dependent on the types of membrane lipids… CONTINUE READING

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