Ca(2+)-dependent and -independent Cl(-) secretion stimulated by the nitric oxide donor, GEA 3162, in rat colonic epithelium.

@article{Schulthei2002Ca2dependentA,
  title={Ca(2+)-dependent and -independent Cl(-) secretion stimulated by the nitric oxide donor, GEA 3162, in rat colonic epithelium.},
  author={G. F. Schulthei\ss and Gisela Seip and Sarah L{\'a}n Kocks and Martin Diener},
  journal={European journal of pharmacology},
  year={2002},
  volume={444 1-2},
  pages={21-30}
}
The lipophilic nitric oxide-liberating drug, 1,2,3,4-oxatriazolium,5-amino-3-(3,4-dichlorophenyl)-chloride (GEA 3162), concentration-dependently induced a Cl(-) secretion in rat colon. At a low concentration (5 x 10(-5) M), the action was Ca(2+)-dependent, whereas at a high concentration (5 x 10(-4) M), the response was independent from extracellular Ca(2… CONTINUE READING