CYR61 and alphaVbeta5 integrin cooperate to promote invasion and metastasis of tumors growing in preirradiated stroma.

@article{Monnier2008CYR61AA,
  title={CYR61 and alphaVbeta5 integrin cooperate to promote invasion and metastasis of tumors growing in preirradiated stroma.},
  author={Yan Monnier and Pierre Farmer and Gr{\'e}gory Bieler and Natsuko Imaizumi and Thierry Sengstag and Gian Carlo Alghisi and Jean-Christophe Stehle and Laura Ciarloni and Snezana Andrejevic-Blant and Rapha{\"e}l Moeckli and Ren{\'e}-Olivier Mirimanoff and Simon L. Goodman and Mauro Delorenzi and Curzio R{\"u}egg},
  journal={Cancer research},
  year={2008},
  volume={68 18},
  pages={
          7323-31
        }
}
Radiotherapy is widely used to treat human cancer. Patients locally recurring after radiotherapy, however, have increased risk of metastatic progression and poor prognosis. The clinical management of postradiation recurrences remains an unresolved issue. Tumors growing in preirradiated tissues have an increased fraction of hypoxic cells and are more metastatic, a condition known as tumor bed effect. The transcription factor hypoxia inducible factor (HIF)-1 promotes invasion and metastasis of… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 51 REFERENCES

Integrin inhibitors reaching the clinic.

  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2007
VIEW 1 EXCERPT

Hypoxia signalling in cancer and approaches to enforce tumour regression

Jacques Pouysségur, Frédéric Dayan, Nathalie M. Mazure
  • Nature
  • 2006
VIEW 2 EXCERPTS

Genes thatmediate breast cancer metastasis to lung

MinnAJ, GP Gupta, PM Siegel
  • Nature
  • 2005
VIEW 1 EXCERPT