CYP7A1 promoter polymorphism -203A>C affects bile salt synthesis rate in patients after ileal resection.

Abstract

Cholesterol 7alpha-hydroxylase (CYP7A1) plays a crucial role in cholesterol metabolism and has been implicated in genetic susceptibility to atherosclerosis. Thus, an understanding of its transcriptional regulation is of considerable importance. We evaluated the effect of a common -203A>C polymorphism in the CYP7A1 promoter region on the activity of CYP7A1… (More)
DOI: 10.1194/jlr.M800364-JLR200

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@article{Lenek2008CYP7A1PP, title={CYP7A1 promoter polymorphism -203A>C affects bile salt synthesis rate in patients after ileal resection.}, author={Martin Len{\'i}{\vc}ek and Viktor Kom{\'a}rek and Miluse Zimolov{\'a} and Jan Kov{\'a}ř and Milan Jirsa and Milan Luk{\'a}{\vs} and Libor V{\'i}tek}, journal={Journal of lipid research}, year={2008}, volume={49 12}, pages={2664-7} }