CYP7A1, BAAT and UGT1A1 polymorphisms and susceptibility to anti-tuberculosis drug-induced hepatotoxicity.

@article{Chen2016CYP7A1BA,
  title={CYP7A1, BAAT and UGT1A1 polymorphisms and susceptibility to anti-tuberculosis drug-induced hepatotoxicity.},
  author={Ru Chen and Jin Wei Wang and S Tang and Yuqing Zhang and X Lv and S-S Wu and Z Yang and Y Y Xia and D Chen and S Zhan},
  journal={The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease},
  year={2016},
  volume={20 6},
  pages={812-8}
}
SETTING Evidence indicates that the polymorphisms in genes involved in bile acid metabolism may play an important role in the development of anti-tuberculosis drug-induced hepatotoxicity (ATDH) in tuberculosis (TB) patients treated with anti-tuberculosis drugs. OBJECTIVE To investigate the association between genetic variants of CYP7A1, BAAT and UGT1A1 and the risk of ATDH in a Chinese cohort. DESIGN In this nested case-control study, 89 TB patients with ATDH and 356 matched ATDH-free TB… CONTINUE READING