CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts.

@article{Guo2013CYP76AH1CT,
  title={CYP76AH1 catalyzes turnover of miltiradiene in tanshinones biosynthesis and enables heterologous production of ferruginol in yeasts.},
  author={Juan Guo and Yongjin J Zhou and Matthew Lee Hillwig and Ye Shen and Lei Yang and Yajun Wang and Xianan Zhang and Wujun Liu and Reuben J Peters and Xiaoya Chen and Zongbao K Zhao and Lu-Qi Huang},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2013},
  volume={110 29},
  pages={
          12108-13
        }
}
Cytochrome P450 enzymes (CYPs) play major roles in generating highly functionalized terpenoids, but identifying the exact biotransformation step(s) catalyzed by plant CYP in terpenoid biosynthesis is extremely challenging. Tanshinones are abietane-type norditerpenoid naphthoquinones that are the main lipophilic bioactive components of the Chinese medicinal herb danshen (Salvia miltiorrhiza). Whereas the diterpene synthases responsible for the conversion of (E,E,E)-geranylgeranyl diphosphate… CONTINUE READING

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