• Corpus ID: 21873921

CYP4F2 1347 G>A & GGCX 12970 C>G polymorphisms: frequency in north Indians & their effect on dosing of acenocoumarol oral anticoagulant

@article{Rathore2014CYP4F21G,
  title={CYP4F2 1347 G>A \& GGCX 12970 C>G polymorphisms: frequency in north Indians \& their effect on dosing of acenocoumarol oral anticoagulant},
  author={Saurabh Singh Rathore and Surendra Kumar Agarwal and Shantanu Pande and Sushil Kumar Singh and Tulika Mittal and Balraj Mittal},
  journal={The Indian Journal of Medical Research},
  year={2014},
  volume={139},
  pages={572 - 578}
}
Background & objectives: CYP4F2 and γ-glutamyl carboxylase (GGCX) have small but significant roles in the maintenance dose of coumarinic oral anticoagulants (COAs). CYP4F2 1347 G>A and GGCX 12970 C>G polymorphisms have been used in the pharmacogenetic dosing algorithms of warfarin for Caucasians and Chinese populations. India has a large population with multiple ethnic groups but there are no reports about the frequencies of these polymorphisms in north Indians. In the present study, we aimed… 

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