CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever

@inproceedings{Marcsisin2013CYP450PA,
  title={CYP450 phenotyping and metabolite identification of quinine by accurate mass UPLC-MS analysis: a possible metabolic link to blackwater fever},
  author={Sean R Marcsisin and Xiannu Jin and Theresa Bettger and Nicholas McCulley and Jason C Sousa and G Dennis Shanks and Babu L. Tekwani and Rajnish Sahu and Gregory Adam Reichard and Richard J. Sciotti and V{\'i}ctor Mel{\'e}ndez and Brandon S. Pybus},
  booktitle={Malaria Journal},
  year={2013}
}
BackgroundThe naturally occurring alkaloid drug, quinine is commonly used for the treatment of severe malaria. Despite centuries of use, its metabolism is still not fully understood, and may play a role in the haemolytic disorders associated with the drug.MethodsIncubations of quinine with CYPs 1A2, 2C9, 2C19, 2D6, and 3A4 were conducted, and the metabolites were characterized by accurate mass UPLC-MSE analysis. Reactive oxygen species generation was also measured in human erythrocytes… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 24 REFERENCES

Blackwater fever in southern Vietnam: a prospective descriptive study of 50 cases.

  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 1996
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL