CYP450 pharmacogenetic treatment strategies for antipsychotics: a review of the evidence.

@article{Ravyn2013CYP450PT,
  title={CYP450 pharmacogenetic treatment strategies for antipsychotics: a review of the evidence.},
  author={Dana Ravyn and Vipa Ravyn and Robert Lowney and Henry A Nasrallah},
  journal={Schizophrenia research},
  year={2013},
  volume={149 1-3},
  pages={1-14}
}
Although a number of first- and second-generation antipsychotics are available, achieving optimal therapeutic response for patients with schizophrenia can be challenging. The presence of polymorphic alleles for cytochrome P (CYP) 450 may result in lack of expression, altered levels of expression, or altered function of CYP450 enzymes. CYP2D6, CYP1A2, and CYP3A4/5 are major enzymes in the metabolism of antipsychotics and polymorphisms of alleles for these proteins are associated with altered… CONTINUE READING