CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±)-14,15-epoxyeicosatrienoic acid (EET).

@article{Mitra2011CYP3A4MG,
  title={CYP3A4 mediates growth of estrogen receptor-positive breast cancer cells in part by inducing nuclear translocation of phospho-Stat3 through biosynthesis of (±)-14,15-epoxyeicosatrienoic acid (EET).},
  author={Ranjana Mitra and Zhijun Guo and Monica Milani and Clementina A Mesaros and Mariangellys Rodriguez and Julia Nguyen and Xianghua Luo and Duncan J Clarke and J. Lamba and Erin G. Schuetz and David B. Donner and Narender Puli and John R Falck and J. Capdevila and Kalpna Gupta and Ian A Blair and David A. Potter},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 20},
  pages={17543-59}
}
CYP3A4 expression in breast cancer correlates with decreased overall survival, but the mechanisms are unknown. Cytochrome P450 gene profiling by RNAi silencing demonstrates that CYP3A or 2C8 gene expression is specifically required for growth of the breast cancer lines MCF7, T47D, and MDA-MB-231. CYP3A4 silencing blocks the cell cycle at the G(2)/M checkpoint and induces apoptosis in the MCF7 line, thereby inhibiting anchorage-dependent growth and survival. CYP3A4 was profiled for NADPH… CONTINUE READING
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