CYP3A4 is mainly responsibile for the metabolism of a new vinca alkaloid, vinorelbine, in human liver microsomes.

@article{Kajita2000CYP3A4IM,
  title={CYP3A4 is mainly responsibile for the metabolism of a new vinca alkaloid, vinorelbine, in human liver microsomes.},
  author={Jiro Kajita and Takashi Kuwabara and Hiroyuki Kobayashi and Satoshi Kobayashi},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2000},
  volume={28 9},
  pages={1121-7}
}
The metabolism of vinorelbine, a new anticancer agent belonging to the vinca alkaloid family, was investigated in human liver microsomes. Vinorelbine biotransformation consisted of one saturable and one nonsaturable process, and the K(m) and V(max) values for the saturable process were 1.90 microM and 25.3 pmol/min/mg of protein, respectively. Several studies, including metabolism by cytochrome P450 (CYP) enzymes in a cDNA expression system and inhibition by specific antibodies and chemical… CONTINUE READING

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