CYP3A4 inducible model for in vitro analysis of human drug metabolism using a bioartificial liver.

@article{Iwahori2003CYP3A4IM,
  title={CYP3A4 inducible model for in vitro analysis of human drug metabolism using a bioartificial liver.},
  author={Tohru Iwahori and Tomokazu Matsuura and Haruka Maehashi and Ken Sugo and Masaya Saito and Masakiyo Hosokawa and Kan Chiba and Takahiro Masaki and Hideki Aizaki and Kiyoshi Ohkawa and Tetsuro Suzuki},
  journal={Hepatology},
  year={2003},
  volume={37 3},
  pages={
          665-73
        }
}
CYP3A is responsible for approximately 50% of the therapeutic drug-metabolizing activity in the liver. The present study was undertaken to establish the CYP3A4 inducible model for analysis of human drug metabolism using a bioartificial liver composed of the functional hepatocellular carcinoma cell (HCC) line FLC-5. A radial-flow bioreactor (RFB), which is a carrier-filled type bioreactor, was used for 3-dimensional perfusion culture of FLC-5 cells. The CYP3A4 messenger RNA (mRNA) expression… CONTINUE READING
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