CYP3A4 catalytic activity is induced in confluent Huh7 hepatoma cells.

@article{Sivertsson2010CYP3A4CA,
  title={CYP3A4 catalytic activity is induced in confluent Huh7 hepatoma cells.},
  author={Louise K Sivertsson and Monica Ek and Malin Darnell and Irene Edebert and Magnus Ingelman-Sundberg and Etienne P. A. Neve},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2010},
  volume={38 6},
  pages={995-1002}
}
Drug-induced hepatotoxicity is an important cause for disapproval, limitations of use, or withdrawal of drugs, and there is a high need for reproducible in vitro systems that can predict such toxicity. In this study, we show that confluent growth of the human hepatoma cell line Huh7 up to 5 weeks results in increased gene expression of several cytochromes… CONTINUE READING